Histologic changes in the auditory tube mucosa of rats after long-term exposure to cigarette smoke
Histologic changes in the auditory tube mucosa of rats after long-term exposure to cigarette smoke
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DOI：
10.1016/j.amjoto.2008.07.009
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发表时间：
2009-11-01
影响因子：
2.5
通讯作者：
Wang, Soo-Geun
中科院分区：
文献类型：
--
作者：
Kong, Soo-Keun;Chon, Kyong-Myong;Wang, Soo-Geun
目的：探讨香烟烟雾长期暴露(4个月和6个月)对大鼠听道和中耳粘膜的影响。实验组在吸烟室中吸烟4个月和6个月(n=5)。对照组(n=5)放在同一房间内，不暴露于香烟烟雾中。光镜和电子显微镜下观察耳道粘膜的组织学变化。结果：中耳黏膜组织学改变主要表现为杯状细胞增殖，耳道粘液分泌增多。鳞状化生随暴露于耳道的时间长短而相反地减少。随着暴露于听道和中耳的时间延长，杯状细胞数量逐渐增多。结论：长期被动吸烟直接影响听道和中耳粘膜。耳道粘膜组织学改变主要表现为杯状细胞增殖和粘液分泌增多。(C)2009 Elsevier Inc.保留所有权利。
Purpose: The aim of the study was to investigate the effect of cigarette smoke on the auditory tube and middle ear mucosa after long-term exposure (4 and 6 months).Materials and methods: Fifteen rats were divided into 3 groups. The experimental groups were exposed to cigarette in a smoking chamber for 4 and 6 months (n = 5 each). A control group (n = 5) was placed in the same chamber without exposure to cigarette smoke. Histologic changes of the auditory tube mucosa were observed through light and electron microscopes. Histologic changes of the middle ear mucosa were also observed through light microscopes.Results: The histologic changes consisted of a proliferation of goblet cells and an increase of mucus secretion in auditory tube. Squamous metaplasia was paradoxically decreased according to the duration of exposure in auditory tube. The number of goblet cell was gradually increased according to the duration of exposure in the auditory tube and middle ear.Conclusions: Long-term passive smoke directly affects the auditory tube and middle car mucosa. Histologic changes of auditory tube mucosa consisted of goblet cell proliferation and excessive mucus secretion. (c) 2009 Elsevier Inc. All rights reserved.