Relationships Between Disease Activity and Serum and Fecal Biomarkers in Patients With Crohn's Disease
Relationships Between Disease Activity and Serum and Fecal Biomarkers in Patients With Crohn's Disease
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DOI：
10.1016/j.cgh.2008.06.010
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发表时间：
2008-11-01
影响因子：
12.6
通讯作者：
Sandborn, William J.
中科院分区：
文献类型：
--
作者：
Jones, Jennifer;Loftus, Edward V., Jr.;Sandborn, William J.
背景和目标：用于测量克罗恩病患者临床、内镜和生物学疾病活动性的仪器和检测之间的定量关系特征不明确。本研究评价了克罗恩病活动指数（CDAI）、克罗恩病简易内镜评分（SES-CD）、血清高敏C反应蛋白（hsCRP）（表型和基因型）和白细胞介素-6（IL-6）以及粪便钙卫蛋白和乳铁蛋白之间的相关性。方法：共纳入164例接受结肠镜检查的克罗恩病患者。检测CDAI和SES-CD评分、血清hsCRP和IL-6、CRP和IL-6基因型以及粪便钙卫蛋白和乳铁蛋白。结果如下：CDAI与SES-CD评分之间（斯皮尔曼等级相关系数，0.15）或CDAI评分与血清hsCRP和IL-6浓度之间或粪便钙卫蛋白和乳铁蛋白浓度之间无显著相关性。与此相反，在内镜疾病活动性较严重的患者（SES-CD评分> 7分）中，血清hsCRP和IL-6浓度以及粪便钙卫蛋白和乳铁蛋白浓度显著升高（P
Background & Aims: The quantitative relationships between instruments and assays that measure clinical, endoscopic, and biologic disease activity in patients with Crohn's disease are poorly characterized. This study evaluated the correlations between the Crohn's Disease Activity Index (CDAI), the Simple Endoscopic Score for Crohn's Disease (SES-CD), serum high-sensitivity C-reactive protein (hsCRP) (both phenotype and genotype) and interleukin-6 (IL-6), and fecal calprotectin and lactoferrin. Methods: A total of 164 patients with Crohn's disease undergoing colonoscopy were enrolled. The CDAI and SES-CD scores, serum hsCRP and IL-6, CRP and IL-6 genotypes, and fecal calprotectin and lactoferrin were measured. Results: There were no significant associations between the CDAI and SES-CD scores (Spearman rank correlation coefficient, 0.15) or between the CDAI scores and the serum concentrations of hsCRP and IL-6, or the fecal concentrations of calprotectin and lactoferrin. In contrast, the serum hsCRP and IL-6 concentrations and the fecal calprotectin and lactoferrin concentrations were significantly higher in patients with more severe endoscopic disease activity (SES-CD score > 7 points) (P