Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis.
Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis.
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DOI：
10.1126/science.1230721
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发表时间：
2013-01-11
期刊：
影响因子：
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通讯作者：
Chawla A
中科院分区：
文献类型：
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作者：
Odegaard JI;Chawla A
新陈代谢和免疫之间有着千丝万缕的联系，也与整个生物体的功能密不可分，从而使哺乳动物能够适应其内外环境的变化。然而，在现代肥胖饮食和生活方式的背景下，这些适应性反应可能会产生有害的后果。在这篇综述中，我们讨论了炎症和胰岛素抵抗在代谢稳态和疾病中的多效性作用。对这些反应产生的适应性背景的认识有助于理解它们在疾病中的致病作用。
Metabolism and immunity are inextricably linked both to each other and to organism-wide function, allowing mammals to adapt to changes in their internal and external environments. In the modern context of obesogenic diets and lifestyles, however, these adaptive responses can have deleterious consequences. In this review, we discuss the pleiotropic actions of inflammation and insulin resistance in metabolic homeostasis and disease. An appreciation of the adaptive context in which these responses arose is useful for understanding their pathogenic actions in disease.