Characterization of age-related changes in body weight and organ weights from birth to adolescence in humans
Characterization of age-related changes in body weight and organ weights from birth to adolescence in humans
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DOI：
10.1080/152873901753215911
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发表时间：
2001-11-23
期刊：
影响因子：
--
通讯作者：
Krishnan, K
中科院分区：
文献类型：
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作者：
Haddad, S;Restieri, C;Krishnan, K
化学品的药代动力学和组织剂量可能因人口个体而异，特别是成人和儿童。成人-儿童药代动力学的差异源于与年龄相关的化学物质吸收和处置的生理、生化和物理化学决定因素的变化。本研究的目的是回顾已发表的文献，以收集人体体重和器官重量随年龄（特别是出生至18岁之间）变化的数据，并分析这些数据，以开发回归方程，以年龄作为依赖函数计算儿童体重和器官重量。获得并分析年龄相关体重数据的特定器官/组织包括血液、脂肪组织、肝脏、肺、脑、心脏、肾脏、脾脏、生殖器官（雄性：前列腺、精囊、睾丸和附睾;雌性：卵巢、子宫和输卵管）、腺体（肾上腺、垂体、胸腺、胰腺和甲状腺）、骨髓（全部和红色）、肠道、胃、肌肉、皮肤在男性和女性儿童中，这些器官的总和系统地低于体重，并且这种差异可以通过附加的关于皮下组织重量的数据的可用性和考虑来解决。本文中给出的体重和器官重量的方程和数据对于构建儿童年龄特异性的、基于生理的药代动力学模型是有用的。
The pharmacokinetics and tissue dose of chemicals may differ among individuals of a population, particularly between adults and children. The adult-children differences in pharmacokinetics arise from age-related changes in the physiological, biochemical, and physicochemical determinants of uptake and disposition of chemicals. The objectives of this study were to review the published literature to assemble data on the human body weight and organ weights as a function of age (specifically between birth and 18 yr old) and to analyze these data, in order to develop regression equations for calculating body weight and organ weights of children using age as the dependent function. The specific organs/tissues for which the data on age-related weight were obtained and analyzed include blood, adipose tissues, liver, lungs, brains, heart, kidneys, spleen, the reproductive organs (male: prostate gland, seminal vesicle, testes, and epididymis; female: ovaries, uterus, and uterine tubes), glands (adrenal, pituitary, thymus, pancreas, and thyroid), bone marrow (total and red), intestinal tract, stomach, muscle, skin (epidermis and dermis), and skeleton, In both male and female children, the sum of these organs is systematically lower than the body weight, and this discrepancy may be resolved with the additional availability and consideration of data on hypodermis weight. The equations and data on body weight and organ weights presented in this article should be useful for constructing age-specific, physiologically based pharmacokinetic models for children.