A personal reflection on the Replicon Theory: from R1 plasmid to replication timing regulation in human cells
A personal reflection on the Replicon Theory: from R1 plasmid to replication timing regulation in human cells
复制标题
复制子理论的个人反思：从R1质粒到人体细胞的复制时序调控
DOI：
10.1016/j.jmb.2013.03.039
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
H.
中科院分区：
文献类型：
--
作者：
Masai;H.
在复制子理论提出50年后，人们对原核生物复制子的机制有了详细的认识，并在阐明真核细胞中复制子调控的更复杂的调控机制方面取得了迅速的进展。在这里，我就模型复制子的研究如何有助于我们理解DNA复制的基本机制以及人类细胞复制调控的进化提出我的个人观点。我还将讨论复制调控如何有助于基因组的稳定维持，以及复制调控的中断如何导致人类疾病。
Fifty years after the Replicon Theory was originally presented, detailed mechanistic insight into prokaryotic replicons has been obtained and rapid progress is being made to elucidate the more complex regulatory mechanisms of replicon regulation in eukaryotic cells. Here, I present my personal perspectives on how studies of model replicons have contributed to our understanding of the basic mechanisms of DNA replication as well as the evolution of replication regulation in human cells. I will also discuss how replication regulation contributes to the stable maintenance of the genome and how disruption of replication regulation leads to human diseases.