The Ectodysplasin and NFkappaB signalling pathways in odontogenesis.
The Ectodysplasin and NFkappaB signalling pathways in odontogenesis.
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发表时间：
2005
影响因子：
3
通讯作者：
J. Courtney;J. Blackburn;P. Sharpe
中科院分区：
文献类型：
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作者：
J. Courtney;J. Blackburn;P. Sharpe
少汗性外胚层发育不良（HED）是一种影响外胚层起源器官（包括牙齿、毛发和汗腺）的先天性疾病。外胚层发育异常（虎斑）、Edar（无绒毛）和Edar相关死亡结构域（Edaradd）（起皱）的缺陷会导致人类和小鼠的HED。外胚层发育不良是肿瘤坏死因子（TNF）超家族成员，其下游信号传导由kappaB激酶（IKK）复合物抑制剂和kappaB抑制剂（IkappaB）转导以激活转录因子NF κ B。NF κ B信号传导参与广泛的细胞过程，并且在每个阶段，不同的家族成员必须为每个功能进行严格调节。最近的数据已经证明了这一信号通路在牙发育中的重要性，特别是在牙尖的形成中。在这里，我们回顾了我们对牙齿发育中的外异型增生/NF kappaB信号传导的了解的最新进展，特别是IKK复合体的核心作用。
Hypohidrotic ectodermal dysplasia (HED) is a congenital disorder affecting organs of ectodermal origin including teeth, hair and sweat glands. Defects in Ectodysplasin (tabby), Edar (downless) and Edar associated death domain (Edaradd) (crinkled) cause HED in both humans and mice. Ectodysplasin is a tumour necrosis factor (TNF) superfamily member whose downstream signalling is transduced by the inhibitor of kappaB kinase (IKK) complex and inhibitors of kappaB (IkappaB) to activate the transcription factor NFkappaB. NFkappaB signalling is involved in a wide range of cellular processes and at each stage the different family members must be tightly regulated for each function. Recent data have demonstrated the importance of this signalling pathway in odontogenesis, particularly in the formation of cusps. Here we review recent advances in our understanding of Ectodysplasin/NFkappaB signalling in tooth development and in particular the central role of the IKK complex.