What role does pyroptosis play in cancer?
What role does pyroptosis play in cancer?
复制标题
DOI：
10.1016/j.molmet.2022.101587
复制
发表时间：
2022-11
影响因子：
8.1
通讯作者：
Zhang, Chenliang
中科院分区：
文献类型：
--
作者：
Huang, Chen;Li, Jian;Zhang, Chenliang
近年来，火灾引起了人们的广泛关注。简要比较了它与其他程序性死亡的异同点及其研究过程。随着对caspase-1/3/4/5/8/11等caspase家族的深入研究，对细胞凋亡的分子机制有了新的认识。它还与许多癌症的发展密切相关，这同时为我们提供了治疗癌症的新思路。我们描述了什么是已知的关于细胞凋亡对抗癌免疫的影响，并提供洞察利用细胞凋亡作为一种工具，并将其应用于新的或现有的抗癌策略的潜力。细胞凋亡是一种半胱天冬酶依赖性细胞死亡，导致孔形成、细胞肿胀、质膜破裂和所有细胞内内容物的释放。细胞凋亡在癌症中的作用是一个极其复杂的问题。越来越多的证据表明肿瘤细胞凋亡具有抗肿瘤和促肿瘤作用。应根据癌症发生发展的特点，在不同的癌症时期进行讨论。在肿瘤治疗中，细胞凋亡为我们提供了一些潜在的新靶点。对于现有药物而言，对焦亡的研究也有助于我们更好地利用现有药物进行抗癌治疗。免疫治疗是肿瘤治疗领域的一个热门研究方向。
Pyroptosis has been attracting much attention recently. We have briefly compared its differences and similarities with other programmed deaths and the process of its study. With further exploration of the caspase family, including caspase-1/3/4/5/8/11, new insights into the molecular pathways of action of pyroptosis have been gained. It is also closely related to the development of many cancers, which at the same time provides us with new ideas for the treatment of cancer. We describe what is known regarding the impact of pyroptosis on anticancer immunity and give insight into the potential of harnessing pyroptosis as a tool and applying it to novel or existing anticancer strategies. Pyroptosis, a caspase-dependent cell death, causes pore formation, cell swelling, rupture of the plasma membrane, and release of all intracellular contents. The role of pyroptosis in cancer is an extremely complex issue. There is growing evidence that tumor pyroptosis has anti-tumor and pro-tumor roles. It should be discussed in different cancer periods according to the characteristics of cancer occurrence and development. In cancer treatment, pyroptosis provides us with some potential new targets. For the existing drugs, the study of pyroptosis also helps us make better use of existing drugs for anticancer treatment. Immunotherapy is a hot research direction in the field of cancer treatment.
登录
查看更多内容
影响因子：
29.7
作者：
Davis BK;Wen H;Ting JP
通讯作者：
Ting JP
影响因子：
9
作者：
Chen C;Wang B;Sun J;Na H;Chen Z;Zhu Z;Yan L;Ren S;Zuo Y
通讯作者：
Zuo Y
DOI：
10.1073/pnas.1607769113
发表时间：
2016-07-12
影响因子：
11.1
作者：
Aglietti, Robin A.;Estevez, Alberto;Dueber, Erin C.
通讯作者：
Dueber, Erin C.
影响因子：
4.5
作者：
Carl-Mcgrath, Stacy;Schneider-Stock, Regine;Roecken, Christoph
通讯作者：
Roecken, Christoph
DOI：
10.26355/eurrev_201812_16511
发表时间：
2018-12-01
影响因子：
3.3
作者：
Chen, Y-F;Qi, H-Y;Wu, F-L
通讯作者：
Wu, F-L