Sequential stereodivergent organocatalysis and programmed organocascade
Sequential stereodivergent organocatalysis and programmed organocascade
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顺序立体发散有机催化和程序化有机级联
DOI：
10.1039/c3ob42310g
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Yoshihiro Sohtome and Kazuo Nagasawa
中科院分区：
文献类型：
--
作者：
Yamao Y;Suzuki K;Kunieda T;Matsumoto R;Arakawa Y;Nakae T;Nishida S;Inano R;Shibata S;Shimotake A;Kikuchi;T;Sawamoto N;Mikuni N;Ikeda A;Fukuyama H;Miyamoto S;Yoshihiro Sohtome and Kazuo Nagasawa
在过去的十年中，不对称有机催化作为一种合成策略引起了人们极大的兴趣。但是，尽管有机催化剂对水分和氧气的惰性为调节反应条件提供了很大的机会，但有机催化剂的立体可切换特性尚未得到系统的研究，大多数发现都是偶然的。在这个角度来看，我们强调的重要性，在动态不对称有机催化获得不同的功能结果与单烧瓶操作的原位可调性。
Asymmetric organocatalysis has attracted great interest as a synthetic strategy during the past decade. But, although the inertness of organocatalysts to moisture and oxygen offers great opportunities to tune the reaction conditions, the stereoswitchable character of organocatalysts has not been systematically studied, and most findings have been serendipitous. In this Perspective, we emphasize the importance of in situ tunability in dynamic asymmetric organocatalysis for obtaining different functional outcomes with single-flask operation.