Electrospinning for tissue engineering scaffolds
Electrospinning for tissue engineering scaffolds
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DOI：
10.1016/j.msec.2006.05.019
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发表时间：
2007-04-01
期刊：
影响因子：
--
通讯作者：
Farson, D. F.
中科院分区：
文献类型：
--
作者：
Lannutti, J.;Reneker, D.;Farson, D. F.
组织工程包括制造三维支架以支持细胞内生长和增殖。目标是：产生身体能够适应执行生理功能的“新组织”。为了实现这一代具有定制的、仿生的(跨越多个尺度)几何形状的支架，已经变得重要。与其他技术相比，电纺支架功能的复杂性提供了显著的优势；然而，在体内最佳利用成为常规之前，还需要改进。这种表面上的细胞对地形很敏感。静电纺丝可以改变以影响(1)纤维本身的表面形貌或(2)纺丝纤维网的更大的表面形貌。提高沉积效率是保持这项技术吸引力所必需的进步。虽然残留溶剂在电纺聚合物中的作用尚不清楚，但高压CO可用于增强化学功能，同时保持聚合物的形态。电纺时的孔径通常太小，细胞无法通过。随着组织工程学作为一门分支学科的成熟，以及基本电纺工艺的局限性得到更广泛的认识，这些支架的后处理以改善内部增殖有望产生相当大的好处。(C)2006爱思唯尔B.V.保留所有权利。
Tissue engineering involves fabrication of three-dimensional scaffolds to support cellular in-growth and proliferation. The goal: generation of 'neotissues' that the body can adapt to carry out physiological function. To achieve this generation of scaffolds having tailored, biomimetic (across multiple scales) geometries has become important. The functional complexity of electrospun scaffolds provides significant advantages over other techniques; however, improvements are required before optimal utilization in vivo becomes routine. Cells on such surfaces are sensitive to topography. Electrospinning can be altered to influence either (1) the surface topography of the fibers themselves or (2) the larger topography of the 'web' of spun fibers. Improved deposition efficiencies are a necessary advance needed to maintain the attractiveness of this technique. While the role of residual solvent in the electrospun polymer remains unclear, high pressure CO, can be used to enhance chemical functionality while maintaining polymer morphology. Electrospun pore sizes, as spun, are typically too small for cells to pass through. Post-processing of these scaffolds to improve internal proliferation is expected to yield considerable benefits as tissue engineering matures as a subdiscipline and the limits of the basic electrospinning process are more widely realized. (c) 2006 Elsevier B.V. All rights reserved.