The two-signal model of T-cell activation after 30 years
The two-signal model of T-cell activation after 30 years
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DOI：
10.1097/00007890-200201151-00011
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发表时间：
2002-01-15
期刊：
影响因子：
6.2
通讯作者：
Alberti, I
中科院分区：
文献类型：
--
作者：
Bernard, A;Lamy, L;Alberti, I
T细胞激活的双信号模型在30年后仍然有效。最近对第一个信号的复杂性及其与第二个信号的紧密关系的了解，为T细胞的激活过程以及T细胞表面和内部发生的复杂分子事件提供了决定性的线索。此外，除了CD28和CD40通路外，许多辅助通路的识别揭示了组成第二信号的精细而众多的调节事件，这些辅助通路除了CD28和CD40通路外，还负责管理抗原提呈细胞T细胞的协同作用。
The two-signal model of T-cell activation is still valid after 30 years. The recent understanding of the first signal intricacy and its tight relationship with the second signal have thrown decisive light on T-cell activation processes and the complex molecular events that occur on the surface and within the T cell. Furthermore, the recognition of numerous accessory pathways that, in addition to the CD28 and CD40 pathways, operate to manage antigen-presenting cell T cell cooperation in view of lymphocyte activation, disclose the exquisite and numerous regulatory events that compose the second signal.