Otosclerosis Temporal Bone Pathology
Otosclerosis Temporal Bone Pathology
复制标题
DOI：
10.1016/j.otc.2017.11.001
复制
发表时间：
2018-04-01
影响因子：
1.7
通讯作者：
McKenna, Michael J.
中科院分区：
文献类型：
--
作者：
Quesnel, Alicia M.;Ishai, Reuven;McKenna, Michael J.
耳硬化症的病理特征是骨重塑异常，包括骨吸收、新骨沉积和颞骨中的血管增殖。耳硬化症中的感音神经性听力损失与耳硬化症延伸至耳蜗内膜以及整个螺旋韧带中胶原蛋白的沉积有关。镫骨切除术后持续性或复发性传导性听力损失与足板开窗不完整、砧骨假体连接不良以及颞骨标本中砧骨吸收有关。人类颞骨病理学有助于确定计算机断层扫描成像在耳硬化症中的作用，证实计算机断层扫描对诊断高度敏感，但在评估耳蜗内膜受累方面有限。
Otosclerosis is pathologically characterized by abnormal bony remodeling, which includes bone resorption, new bone deposition, and vascular proliferation in the temporal bone. Sensorineural hearing loss in otosclerosis is associated with extension of otosclerosis to the cochlear endosteum and deposition of collagen throughout the spiral ligament. Persistent or recurrent conductive hearing loss after stapedectomy has been associated with incomplete footplate fenestration, poor incusprosthesis connection, and incus resorption in temporal bone specimens. Human temporal bone pathology has helped to define the role of computed tomography imaging for otosclerosis, confirming that computed tomography is highly sensitive for diagnosis yet limited in assessing cochlear endosteal involvement.