Genetic discrimination and screening for hemochromatosis.
Genetic discrimination and screening for hemochromatosis.
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DOI：
10.2307/3342910
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发表时间：
1994-01-01
影响因子：
3.8
通讯作者：
Natowicz, M R
中科院分区：
文献类型：
--
作者：
Alper, J S;Geller, L N;Natowicz, M R
血色素沉着症基因型检测的最新进展以及将该检测用于该疾病的大规模筛查计划的建议，增加了对血色素沉着症纯合子患者歧视发生率的可能性。本文介绍了从一项关于对具有各种遗传条件的人的歧视的研究中得出的遗传歧视案例。这里讨论的情况涉及就业和几种类型的保险歧视的人被诊断为血色素沉着症谁要么是目前无症状或其条件是通过抽血控制。这些类型的歧视是没有道理的，因为控制血色沉着病的人没有过多的死亡率或发病率。我们的研究表明，遗传歧视已经是一个严重的问题，任何拟议的血色素沉着症或其他遗传疾病的筛查计划都必须考虑并试图减轻其影响。
Recent advances in tests for the genotype for hemochromatosis and suggestions that the tests be used in mass screening programs for the disease raise the possibility of a large increase in the incidence of discrimination against people who are found to be homozygous for hemochromatosis. This paper presents cases of genetic discrimination drawn from a study of discrimination against people with a variety of genetic conditions. The cases discussed here involve employment and several types of insurance discrimination against people diagnosed with hemochromatosis who either are currently asymptomatic or whose condition is controlled by means of phlebotomies. There is no justification for these types of discrimination since people with controlled hemochromatosis suffer no excess mortality or morbidity. Our study suggests that genetic discrimination is already a serious problem and that any proposed screening program for hemochromatosis or other genetic condition must consider and attempt to mitigate its effects.