Neuronal current distribution imaging using magnetic resonance
Neuronal current distribution imaging using magnetic resonance
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DOI：
10.1109/20.800771
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发表时间：
1999-09-01
影响因子：
2.1
通讯作者：
Ueno, S
中科院分区：
文献类型：
--
作者：
Kamei, H;Iramina, K;Ueno, S
开发了一种新的功能磁共振成像(FMRI)技术，用于可视化人脑中神经元电流的分布。利用基于显微磁共振成像技术的方法测量了体模中电流偶极子引起的内部磁场变形。用本方法测得的电流偶极矩的最小值为90nM。这项技术被应用于通过使用运动和感觉刺激范例来获得人类大脑活动的地图。使用1.5T的EPI序列进行测量。通过编辑由不同极性的场梯度获得的功能图像，消除了由神经元电流以外的原因引起的强度变化。清晰地获得了中指和拇指敲击时大脑中神经元电流的MRI图。
A new functional magnetic resonance imaging (fMRI) technique to visualize the distribution of neuronal currents in the human brain was developed Measurements of the internal magnetic field deformation caused by an electric current dipole in a phantom were performed using a method based on the microscopic magnetic resonance imaging technique. The minimal value of the current dipole moment detected by the present method was determined to be 90 nAm. The technique was applied to obtain maps of human brain activity by using motor and sensory stimulus paradigms. Measurements were made with an EPI sequence at 1.5T. Intensity changes, resulting from causes other than neuronal currents, were eliminated by editing functional images obtained with field gradients of different polarities. MRI mapping of the neuronal currents in the brain during middle finger and thumb tapping was clearly obtained.