Phencyclidine-like discriminative stimulus properties of MK-801 in rats.
Phencyclidine-like discriminative stimulus properties of MK-801 in rats.
复制标题
MK-801 在大鼠中具有类似苯环己哌啶的辨别刺激特性。
DOI：
10.1016/0014-2999(88)90498-0
复制
发表时间：
1988
影响因子：
5
通讯作者：
Balster,RL
中科院分区：
文献类型：
--
作者：
Willetts,J;Balster,RL
The discriminative stimulus properties of the N-methyl-D-aspartate (NMDA) antagonist MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine) were investigated in rats trained to discriminate phencyclidine (PCP; 1.25 mg/kg i.p.) from saline on a standard two-lever fixed ratio 32 schedule of food reinforcement. MK-801 was generalized from PCP in a dose-dependent manner, with an ED50of 0.10 mg/kg i.p. The ED50for PCP was 0.7 mg/kg io.p. MK-801 is, therefore, a very potent PCP-like drug which may share cellular mechanisms and other effects with PCP, including the antagonism of NMDA.
