Dose-response analysis of cadmium-induced tubular proteinuria: a study of urinary beta2-microglobulin excretion among workers in a battery factory.
Dose-response analysis of cadmium-induced tubular proteinuria: a study of urinary beta2-microglobulin excretion among workers in a battery factory.
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镉引起的管状蛋白尿的剂量反应分析：电池厂工人尿 β2 微球蛋白排泄的研究。
DOI：
10.1016/0013-9351(77)90106-2
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发表时间：
1977
影响因子：
8.3
通讯作者：
B. Rahnster
中科院分区：
文献类型：
--
作者：
Tord Kjellström;Per;B. Rahnster
该研究涵盖了瑞典电池厂接触氧化镉和氢氧化镍粉尘的240名男性和女性工人。对照组由87名未接触的男性组成。从工厂的空气样本显示，目前的接触水平约为50微克镉/立方米空气。通过测量尿β2-微球蛋白排泄来研究镉诱导的效应。参照组的尿β2-微球蛋白浓度遵循对数正态分布，几何平均值为84 μg/L（调整至比重为1.023）。在185名连续接触镉尘的人群中，尿β2-微球蛋白排泄率随接触时间的延长而增高。接触镉量在50 μg/m3左右的6-12年工人的患病率为19%，对照组为3%。吸烟者的患病率是不吸烟者的三倍。
The study covered 240 male and female workers exposed to cadmium oxide and nickel hydroxide dust in a Swedish battery factory. The control group comprised 87 unexposed males. Air samples from the plant showed the present exposure level to be about 50 μg Cd/m3air. Cadmium-induced effects were studied by measuring urinaryβ2-microglobulin excretion. Urinaryβ2-microglobulin concentration followed a log-normal distribution in the reference group with a geometric mean of 84 μg/liter (adjusted to a specific gravity of 1.023). In the group of 185 persons continuously exposed to cadmium dust in the work environment, the prevalence of increased urinaryβ2-microglobulin excretion increased with employment time. The prevalence was 19% for the workers with 6–12 years of exposure to about 50 μg Cd/m3as compared to 3% for those in the reference group. Smokers had about three times higher prevalence than nonsmokers.