Structural Anatomical Investigation of Long-Term Memory Deficit in Behavioral Frontotemporal Dementia
Structural Anatomical Investigation of Long-Term Memory Deficit in Behavioral Frontotemporal Dementia
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DOI：
10.3233/jad-170771
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发表时间：
2018-01-01
影响因子：
4
通讯作者：
Hornberger, Michael
中科院分区：
文献类型：
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作者：
Bertoux, Maxime;Flanagan, Emma C.;Hornberger, Michael
尽管越来越多的研究表明，行为变异性额颞叶痴呆（bvFTD）在大约一半的病例中可能会出现严重的健忘症，但记忆评估目前是区分bvFTD与阿尔茨海默病（AD）的临床标准。因此，bvFTD中“相对保留的情景记忆”的概念仍然是其与AD临床区别的基础，也是bvFTD诊断的标准。与阿尔茨海默氏症相比，bvFTD并不以真正的健忘症和海马变性为特征，这一观点得到了支持。在这项多中心研究中，我们旨在通过自由提示选择性提醒测试（FCSRT）来研究bvFTD记忆表现的神经相关因素。影像学检查遵循两步程序，首先依靠35名bvFTD和34名add患者的MRI萎缩视觉评分，与29名对照组相比；然后在一部分bvFTD患者中使用基于体素的形态测量（VBM）。结果显示，43%的bvFTD患者表现为真正的健忘症。对视觉评分数据的数据驱动分析显示，在bvFTD中，记忆回忆和存储性能明显由前额叶吻侧和海马/海马周围区域的萎缩预测，类似于轻度AD。VBM导致bvFTD （p(FWE)）
Although a growing body of work has shown that behavioral variant frontotemporal dementia (bvFTD) could present with severe amnesia in approximately half of cases, memory assessment is currently the clinical standard to distinguish bvFTD from Alzheimer's disease (AD). Thus, the concept of "relatively preserved episodic memory" in bvFTD remains the basis of its clinical distinction from AD and a criterion for bvFTD's diagnosis. This view is supported by the idea that bvFTD is not characterized by genuine amnesia and hippocampal degeneration, by contrast to AD. In this multicenter study, we aimed to investigate the neural correlates of memory performance in bvFTD as assessed by the Free and Cued Selective Reminding Test (FCSRT). Imaging explorations followed a two-step procedure, first relying on a visual rating of atrophy of 35 bvFTD and 34ADpatients' MRI, contrasted with 29 controls; and then using voxel-based morphometry (VBM) in a subset of bvFTD patients. Results showed that 43% of bvFTD patients presented with a genuine amnesia. Data-driven analysis on visual rating data showed that, in bvFTD, memory recall & storage performances were significantly predicted by atrophy in rostral prefrontal and hippocampal/perihippocampal regions, similar to mild AD. VBM results in bvFTD (p(FWE)