A propensity score matched comparison of different insulin regimens 1 year after beginning insulin in people with type 2 diabetes
A propensity score matched comparison of different insulin regimens 1 year after beginning insulin in people with type 2 diabetes
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DOI：
10.1111/dom.12147
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发表时间：
2013-12-01
影响因子：
5.8
通讯作者：
Home, P. D.
中科院分区：
文献类型：
--
作者：
Freemantle, N.;Balkau, B.;Home, P. D.
目的 根据观察性 CREDIT（胰岛素治疗 2 型糖尿病患者心血管风险评估）研究中 3031 名受试者的数据，使用倾向评分分析比较开始基础胰岛素、预混胰岛素、进餐+基础或进餐时胰岛素治疗的结果。这种方法克服了观察性研究中常见的基线和未知特征中可能存在的混杂因素。方法在基线和 1 年时收集以前未接受过胰岛素治疗的患者的疗效和安全性结果。使用所有可用基线数据定义倾向评分匹配组，以比较胰岛素治疗方案对的结果。结果在 2659 名拥有可用数据的人中，686 人开始使用预混胰岛素或基础胰岛素，542 人开始使用基础+进餐时间或预混合胰岛素，400 人开始使用基础或基础+进餐时间，实现了倾向得分匹配。三对胰岛素治疗方案之间的 HbA1c 降低没有差异。然而，总体和夜间低血糖的相对风险较低（p=0.010 至 p
AimTo compare using propensity score analysis the outcome of beginning insulin therapy with basal, premix, mealtime+basal or mealtime insulin on the basis of data from 3031 people from the observational CREDIT (Cardiovascular Risk Evaluation in People with Type 2 Diabetes on Insulin Therapy) study. This approach overcomes likely confounding in baseline and unknown characteristics common to observational studies.MethodsEfficacy and safety outcomes were collected at baseline and at 1year in previously insulin-naive people. Propensity score matched groups using all available baseline data were defined to compare outcomes by pairs of insulin regimens.ResultsFrom 2659 people with available data, propensity score matches were achieved for 686 people starting premix or basal insulin, 542 starting basal+mealtime or premix insulin and 400 starting basal or basal+mealtime. HbA1c reduction did not differ between the three pairs of insulin regimens. However, the relative risk of overall and nocturnal hypoglycaemia was lower (p=0.010 to p