Physicochernical behavior of homogeneous series of acetylated chitosans in aqueous solution: Role of various structural parameters
Physicochernical behavior of homogeneous series of acetylated chitosans in aqueous solution: Role of various structural parameters
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DOI：
10.1021/bm0496357
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发表时间：
2005-01-01
影响因子：
6.2
通讯作者：
Domard, A
中科院分区：
文献类型：
--
作者：
Lamarque, G;Lucas, JM;Domard, A
Physicochemical properties of four different homogeneous series of chitosans with degrees of acetylation (DA) and weight-average degrees of polymerization (DPw) ranging from 0 to 70% and 650 to 2600, respectively, were characterized in an ammonium acetate buffer (pH 4.5). Then, the intrinsic viscosity ([eta](0)), the root-mean-square z-average of the gyration radius (R-G,R-z), and the second virial coefficient (A(2)) were studied by viscometry and static light scattering. The conformation of chitosan, according to DA and DPw, was highlighted through the variations of alpha and nu parameters, deduced from the scale laws [eta](0) = KwMwalpha and R-G,R-z = K'M-w(nu), respectively, and the total persistence length (L-p,L-tot). In relation with the different behaviors of chitosan in solution, the conformation varied according to two distinct domains versus DA with a transition range in between. Then, (i) for DA 50%) or became more or less constant (DA < 50%). All the conformations of chitosan with regards to DA and DPw were described in terms of short-distance interactions and excluded volume effect.
