Nodular paragranuloma and progressively transformed germinal centers
Nodular paragranuloma and progressively transformed germinal centers
复制标题
结节性副肉芽肿和逐渐转化的生发中心
DOI：
--
复制
发表时间：
1979
期刊：
影响因子：
--
通讯作者：
K. Lennert
中科院分区：
文献类型：
--
作者：
S. Poppema;E. Kaiserling;K. Lennert
摘要：本文介绍了一种以淋巴细胞为主的结节型霍奇金病的超微结构和免疫组织学结果，并将其与所谓的进行性转化生发中心的结果进行了比较。它们是含有大量淋巴细胞的大滤泡，不仅可以在非特异性淋巴结炎中发现，也可以在结节状旁肉芽肿患者的淋巴结中发现。石蜡切片采用免疫过氧化物酶技术检测胞浆内免疫球蛋白和溶菌酶。所谓的L和H型斯特恩伯格-里德细胞每个细胞含有IgG和一种轻链，这表明这种细胞产生免疫球蛋白。L和H型Sternberg-Reed细胞的超微结构有利于这些细胞的免疫母细胞性质。结论：结节性旁肉芽肿不同于其他类型的霍奇金病，其定位于B细胞区和存在非典型B免疫母细胞。
SummaryUltrastructural and immunohistologic findings in a nodular variant of Hodgkin’s disease with lymphocytic predominance, called nodular paragranuloma, are presented and compared with those in so-called progressively transformed germinal centers. These are large follicles with numerous lymphocytes which can be found not only in nonspecific lymphadenitis, but also in lymph nodes from patients with nodular paragranuloma.The immunoperoxidase technique was applied on paraffin sections to detect intracytoplasmic immunoglobulin and lysozyme. The so-called L & H type Sternberg-Reed cells contained IgG and one type of light chain per cell, suggesting that such cells produce immunoglobulin. The ultrastructure of the L & H type Sternberg-Reed cells favored the immunoblastic nature of these cells.It is concluded that nodular paragranuloma differs from other types of Hodgkin’s disease by its localization in B-cell areas and the presence of atypical B immunoblasts.