The current status of the use of oral medication to prevent HIV transmission.
The current status of the use of oral medication to prevent HIV transmission.
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DOI：
10.1097/coh.0000000000000170
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发表时间：
2015-07
影响因子：
4.1
通讯作者：
Ramjee G
中科院分区：
文献类型：
--
作者：
Mayer KH;Ramjee G
This review was designed to evaluate the progress in studies of the use of oral and topical antiretroviral medication for primary HIV prevention. Non-human primate data has suggested that the administration of antiretroviral medication before or after retroviral exposure can protect against the establishment of chronic infection. Over the past two decades, observational studies have demonstrated the safety of antiretroviral agents for post-exposure prophylaxis (PEP) and more recent efficacy studies have demonstrated that tenofovir with or without emtricitabine can protect against HIV when used as pre-exposure prophylaxis (PrEP). Efficacy studies have been conducted in diverse populations, including men and transgender women who have sex with men, young African heterosexuals, and injection drug users. Three studies in African women evaluating oral and topical tenfovir-based regimens did not demonstrate efficacy, in large part because of suboptimal medication adherence. Further research is underway to determine the optimal ways to provide chemoprophylaxis, the optimal medications, and dosing regimens. PrEP can be effective in decreasing HIV transmission to at risk uninfected persons, but further research is needed to determine the optimal modes of delivery.
