Associations of fluoride exposure with sex steroid hormones among US children and adolescents, NHANES 2013-2016
Associations of fluoride exposure with sex steroid hormones among US children and adolescents, NHANES 2013-2016
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DOI：
10.1016/j.envpol.2020.114003
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发表时间：
2020-05-01
影响因子：
8.9
通讯作者：
Guo, Jing
中科院分区：
文献类型：
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作者：
Bai, Rongpan;Huang, Yun;Guo, Jing
氟化物介导的性类固醇激素的破坏已在动物中得到证实。然而，来自人类的证据是有限的和矛盾的，特别是对儿童和青少年。基于2013-2016年国家健康与营养调查（NHANES）的数据，本横断面研究共分析了3392名6 - 19岁的受试者。使用离子特异性电极对血浆和水中的氟化物水平进行电测定量。检测血清中总睾酮、雌二醇和性激素结合球蛋白（SHBG）。通过性别和年龄分层，使用调整的线性回归模型估计与氟化物水平三分位数相关的性类固醇激素的百分比变化和95%置信区间（Cis）（将第一个设为参考）。与血浆氟水平第一个三分位数的受试者相比，第二个和第三个三分位数的睾酮变化百分比（95%CI）分别为-8.08%（-17.36%，2.25%）和-21.65%（-30.44%，-11.75%）（P-趋势
Fluoride mediated disruption of sex steroid hormones has been demonstrated in animals. However, evidence from humans was limited and contradictory, especially for children and adolescents. Based on data of the National Health and Nutrition Survey (NHANES) 2013-2016, a total of 3392 subjects aged 6 -19 years were analyzed in this cross-sectional study. Both plasma and water fluoride levels were quantified electrometrically using the ion-specific electrode. Sex steroid hormones of total testosterone, estradiol and sex hormone-binding globulin (SHBG) were tested in serum. Percent changes and 95% confidence intervals (Cis) in sex steroid hormones associated with tertiles of fluoride levels (setting the first as reference) were estimated using adjusted linear regression models by stratification of gender and age. Compared with subjects at the first tertile of plasma fluoride, percent changes (95% CIs) in testosterone were -8.08% (-17.36%, 2.25%) and -21.65% (-30.44%, -11.75%) for the second and third tertiles, respectively (P- trend