Prognostic impact of trisomy 21 in follicular lymphoma.
Prognostic impact of trisomy 21 in follicular lymphoma.
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21 三体对滤泡性淋巴瘤的预后影响。
DOI：
10.1111/bjh.15664
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Tsukamoto N.
中科院分区：
文献类型：
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作者：
Mitsui T;Yokohama A;Koiso H;Saito A;Toyama K;Shimizu H;Ishizaki T;Irisawa H;Takizawa M;Saitoh T;Murayama K;Matsumoto M;Handa H;Hirato J;Kojima M;Murakami H;Tsukamoto N.
与滤泡性淋巴瘤(FL)预后相关的染色体异常尚未完全阐明。在这里，我们评估了FL的染色体异常模式，并阐明了细胞遗传学特征与临床结果之间的相关性。采用Giemsa显带的标准方法对2001-2013年间收治的201例FL患者进行细胞遗传学分析。发现的染色体异常有：t(14；18)(q32；Q21)(59.2%)，+X(17.9%)，del(6)(Q)/-6(16.9%)，+7(14.4%)，1q12-21/1q(12.9%)，del(13)(Q)/-13(11.9%)，3q27(10.4%)，10q22-24(10.0%)，+12/dup(12)(Q)(10.0%)，1p21-22/1p(9.0%)，+18(9.0%)，del(17)(P)/-17(5.0%)，复杂核型(54.7%)。与非21三体患者相比，21三体患者的无进展生存期(P=0.00)和总生存期(OS)均显著缩短(P=0.00·00171)；此外，利妥昔单抗治疗组中21三体患者的OS也显著缩短(P=0.000)。多因素分析显示，21三体是有或无t(14；18)的独立危险因素(P=10.015)。综上所述，21三体的存在是IN FL的独立危险因素。FL患者确诊时的染色体分析可以为他们的预期生存提供有用的信息。
The chromosomal abnormalities associated with follicular lymphoma (FL) prognosis are not fully elucidated. Here, we evaluated the pattern of chromosomal abnormalities in FL, and clarified the correlations between the cytogenetic features and clinical outcome. Cytogenetic analysis was performed using standard methods of Giemsa‐banding at diagnosis for 201 FL patients admitted to our hospitals between 2001 and 2013. The identified chromosomal abnormalities were: t(14;18)(q32;q21) (59·2%), +X (17·9%), del(6)(q)/‐6 (16·9%), +7 (14·4%), abnormality of 1q12‐21/1q (12·9%), del(13)(q)/‐13 (11·9%), abnormality of 3q27 (10·4%), abnormality of 10q22‐24 (10·0%), +12/dup(12)(q) (10·0%), abnormality of 1p21‐22/1p (9·0%), +18 (9·0%), del(17)(p)/‐17 (5·0%), and a complex karyotype (54·7%). Patients with trisomy 21 had a significantly shorter progression‐free survival (P= 0·00171) and overall survival (OS) (P< 0·001) than those without trisomy 21; additionally, patients with trisomy 21 in the rituximab‐treated cohort also had a significantly shorter OS (P= 0·000428). Multivariate analysis identified trisomy 21 as an independent risk factor in our cohorts with or without t(14;18) (P= 0·015). In conclusion, the presence of trisomy 21 was an independent risk factor for in FL. Chromosomal analysis of FL patients at diagnosis can provide useful information about their expected survival.