Treatment of bladder dysfunction using stem cell or tissue engineering technique.
Treatment of bladder dysfunction using stem cell or tissue engineering technique.
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DOI：
10.4111/kju.2014.55.4.228
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Song YS
中科院分区：
文献类型：
--
作者：
Kim JH;Lee HJ;Song YS
组织工程和干细胞移植是两个重要的选择，可能有助于克服目前膀胱功能障碍治疗策略的局限性。干细胞疗法在治疗病理生理学以及泌尿外科组织工程和再生方面具有很大的前景。迄今为止，泌尿外科的干细胞治疗主要集中在肿瘤和勃起功能障碍。干细胞（SC）的治疗效力最初被认为来自于它们分化成各种细胞类型（包括平滑肌）的能力。SC重建或恢复膀胱功能的主要机制是迁移、分化和旁分泌作用。近年来，干细胞的旁分泌效应被认为是更为突出的，因为它们对干细胞和邻近细胞具有刺激作用。干细胞治疗膀胱功能障碍的研究一直局限于实验模型，并已较少集中在组织工程膀胱再生。膀胱出口梗阻是一种具有代表性的模型。脂肪来源的干细胞、骨髓干细胞（BMSC）和骨骼肌来源的干细胞或肌肉前体细胞用于移植以治疗膀胱功能障碍。本研究的目的是回顾干细胞治疗和更新的组织再生作为治疗膀胱功能障碍，并提供干细胞治疗和组织工程膀胱功能障碍的现状，包括其机制和局限性。
Tissue engineering and stem cell transplantation are two important options that may help overcome limitations in the current treatment strategy for bladder dysfunction. Stem cell therapy holds great promise for treating pathophysiology, as well as for urological tissue engineering and regeneration. To date, stem cell therapy in urology has mainly focused on oncology and erectile dysfunction. The therapeutic potency of stem cells (SCs) was originally thought to derive from their ability to differentiate into various cell types including smooth muscle. The main mechanisms of SCs in reconstituting or restoring bladder function are migration, differentiation, and paracrine effects. Nowadays, paracrine effects of stem cells are thought to be more prominent because of their stimulating effects on stem cells and adjacent cells. Studies of stem cell therapy for bladder dysfunction have been limited to experimental models and have been less focused on tissue engineering for bladder regeneration. Bladder outlet obstruction is a representative model. Adipose-derived stem cells, bone marrow stem cells (BMSCs), and skeletal muscle-derived stem cells or muscle precursor cells are used for transplantation to treat bladder dysfunction. The aim of this study is to review stem cell therapy and updated tissue regeneration as treatments for bladder dysfunction and to provide the current status of stem cell therapy and tissue engineering for bladder dysfunction including its mechanisms and limitations.