Correlation of thrombosis growth rate to pathological wall shear rate during platelet accumulation
Correlation of thrombosis growth rate to pathological wall shear rate during platelet accumulation
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DOI：
10.1002/bit.24537
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发表时间：
2012-10-01
影响因子：
3.8
通讯作者：
Ku, David N.
中科院分区：
文献类型：
--
作者：
Bark, David L., Jr.;Para, Andrea N.;Ku, David N.
局部血流动力学可能强烈影响动脉粥样硬化血栓形成，这可能导致急性心肌梗死和中风。通过一个狭窄的体外流动系统，研究了血小板聚集过程中血液动力学与血栓形成的关系。具体而言，壁剪切率（WSR）范围从0到100,000？s-1通过计算确定，并与每个实验超过5,000个单独观察点的图像分析发现的血栓生长速率进行比较。正相关（P6，000？s-1（P？
Local hemodynamics may strongly influence atherothrombosis, which can lead to acute myocardial infarction and stroke. The relationship between hemodynamics and thrombosis during platelet accumulation was studied through an in vitro flow system consisting of a stenosis. Specifically, wall shear rates (WSR) ranging from 0 to 100,000?s-1 were ascertained through computations and compared with thrombus growth rates found by image analysis for over 5,000 individual observation points per experiment. A positive correlation (P6,000?s-1 (P?