Marrow stromal cells as steam cells for nonhematopoietic tissues
Marrow stromal cells as steam cells for nonhematopoietic tissues
复制标题
DOI：
10.1126/science.276.5309.71
复制
发表时间：
1997-04-04
期刊：
影响因子：
56.9
通讯作者：
Prockop, DJ
中科院分区：
文献类型：
--
作者：
Prockop, DJ
骨髓基质细胞可以通过其粘附于组织培养塑料的倾向而从骨髓中的其他细胞中分离出来：这些细胞具有可以大致定义为间充质的组织的干细胞的许多特征，因为它们可以在培养中分化成成骨细胞、软骨细胞、脂肪细胞甚至成肌细胞。因此，骨髓基质细胞提出了一个有趣的模型，检查干细胞的分化。此外，它们具有几个特性，使它们对细胞和基因治疗有潜在的用处。
Marrow stromal cells can be isolated from other cells in marrow by their tendency to adhere to tissue culture plastic: The cells have many df the characteristics of stem cells for tissues that can roughly be defined as mesenchymal, because they can be differentiated in culture into osteoblasts, chondrocytes, adipocytes, and even myoblasts. Therefore, marrow stromal cells present an intriguing model for examining the differentiation of stem cells. Also, they have several characteristics that make them potentially useful for cell and gene therapy.