The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer
The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer
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CYP4Z1和假基因CYP4Z2P的竞争性内源RNA网络在乳腺癌中发挥抗凋亡功能
DOI：
10.1002/1873-3468.12608
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发表时间：
2017-04-01
期刊：
影响因子：
3.5
通讯作者：
Xi, Tao
中科院分区：
文献类型：
--
作者：
Li, Cheng;Zheng, Lufeng;Xi, Tao
竞争内源性RNA网络（ceRNET）参与肿瘤发生已成为研究热点。CYP4Z1和假基因CYP4Z2P之间的ceRNET促进血管生成并介导乳腺癌的他莫昔芬耐药。然而，ceRNET对细胞凋亡的影响及其相关机制尚不清楚。在本研究中，我们发现下调CYP4Z1或CYP4Z2P 3 '-UTR可促进细胞凋亡，反映了人类端粒酶逆转录酶（hTERT）的功能。此外，CYP4Z1和假基因CYP4Z2P之间的ceRNET通过作为hTERT的子ceRNET来调节hTERT的表达。我们的数据表明，CYP4Z1和假基因CYP4Z2P之间的ceRNET作为hTERT的亚ceRNET，从而抑制乳腺癌细胞凋亡。
The competing endogenous RNA network (ceRNET) is involved in tumorigenesis and has become a hot spot of research. The ceRNET between CYP4Z1 and the pseudogene CYP4Z2P promotes angiogenesis and mediates tamoxifen resistance in breast cancer. Nevertheless, the effects of this ceRNET on cell apoptosis and related mechanisms remain unclear. In the present study, we found that downregulation of CYP4Z1 or the CYP4Z2P 3 '-UTR promotes cell apoptosis, mirroring the functions of human telomerase reverse transcriptase (hTERT). Furthermore, the ceRNET between CYP4Z1 and pseudogene CYP4Z2P modulates hTERT expression by operating as a sub-ceRNET for hTERT. Our data demonstrate that the ceRNET between CYP4Z1 and pseudogene CYP4Z2P acts as a sub-ceRNET for hTERT and, thus, inhibits breast cancer apoptosis.