Experimental and modeling investigation on the rheological behavior of collagen solution as a function of acetic acid concentration
Experimental and modeling investigation on the rheological behavior of collagen solution as a function of acetic acid concentration
复制标题
胶原蛋白溶液流变行为随乙酸浓度变化的实验和模型研究
DOI：
10.1016/j.jmbbm.2017.09.003
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发表时间：
2018-01-01
影响因子：
3.9
通讯作者：
Li, Guoying
中科院分区：
文献类型：
--
作者：
Yang, Huan;Duan, Lian;Li, Guoying
对胶原蛋白溶液（10 mg/mL）的流变行为作为乙酸（AA）浓度（0.1-10 M）的函数进行了系统分析，以实现对胶原蛋白分子与酸性溶剂之间的相互作用的更深入的理解。稳态剪切试验表明，所有试样均表现出假塑性剪切变稀行为。在0.1 s（-1）时，粘度从236.448 Pa.s降低到0.792 Pa.s，表明胶原溶液的流动能力随着AA浓度的增加而改善。动态频率扫描分析表明，储能模量，损耗模量，和复数粘度随着AA浓度的增加，由于胶原分子的解缠结，而损耗角正切增加。通过触变测量确定胶原溶液的滞后环面积，这表明较弱的触变行为与较高的AA浓度相关。此外，抗变形和弹性的能力在较高的AA浓度降低。最大柔度值从0.042增加到376.407 Pa-1，回收率从97.670%下降到0.315%。最后，利用相应的数学模型对实验数据进行了模拟和定量评估。
Systematic analysis of the rheological behavior of collagen solution (10 mg/mL) as a function of acetic acid (AA) concentration (0.1-10 M) was performed to achieve a deeper understanding about the interaction between collagen molecules and acidic solvent. Steady shear tests showed that all samples exhibited pseudo-plasticity with shear-thinning behavior. Viscosity decreased from 236.448 to 0.792 Pa.s at 0.1 s(-1) suggesting the flow ability of collagen solution improved with increasing AA concentration. Dynamic frequency sweep analysis revealed that the storage modulus, loss modulus, and complex viscosity decreased with the increased AA concentration due to the disentanglement of collagen molecules, while the loss tangent increased. Hysteresis loop areas of collagen solutions were determined by thixotropic measurement, which demonstrated that weaker thixotropic behavior was associated with higher AA concentrations. Furthermore, the ability to resist deformation and elasticity was lower at higher AA concentration. Maximum compliance values increased from 0.042 to 376.407 Pa-1, and the recovery percentage decreased from 97.670% to 0.315%. Finally, corresponding mathematical models were employed to simulate and quantitatively assess the experimental data.