ASSOCIATION BETWEEN MALIGNANT DISEASE IN CHILDREN AND MATERNAL VIRUS-INFECTIONS
ASSOCIATION BETWEEN MALIGNANT DISEASE IN CHILDREN AND MATERNAL VIRUS-INFECTIONS
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DOI：
10.1136/bmj.1.5855.706
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发表时间：
1973-01-01
影响因子：
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通讯作者：
GORBACH, PD
中科院分区：
文献类型：
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作者：
BITHELL, JF;DRAPER, GJ;GORBACH, PD
使用牛津儿童癌症调查的回顾性数据，研究了妊娠期间病毒感染与儿童随后恶性疾病之间相关性的可能性。流感、水痘和风疹似乎都存在这种关联。对于流感和风疹，估计风险很小;数据不允许直接对水痘进行估计。这表明，母亲水痘和神经系统肿瘤之间可能存在特定的联系，需要强调的是，即使与这些病毒相关的相对风险相当大，但实际上可归因于它们的儿童癌症和白血病病例数量可能非常少。
The possibility of an association between virus infections during pregnancy and subsequent malignant disease in the child has been investigated using retrospective data from the Oxford Survey of Childhood Cancers. Such an association appears to exist for influenza, chickenpox, and possibly rubella. For influenza and rubella the estimated risk is small; the data do not permit an estimate to be made directly in the case of chickenpox. It is suggested that there may be a specific association between maternal chickenpox and tumours of the nervous system.It is important to emphasize that, even if the relative risk associated with these viruses is fairly large, the number of cases of childhood cancer and leukaemia actually attributable to them is probably very small.