Evidence for linkage between HL-A histocompatibility genes and those involved in the synthesis of the second component of complement.
Evidence for linkage between HL-A histocompatibility genes and those involved in the synthesis of the second component of complement.
复制标题
HL-A组织相容性基因与参与补体第二个组成部分的基因之间的联系的证据。
DOI：
10.1084/jem.140.4.1108
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发表时间：
1974-10-01
影响因子：
15.3
通讯作者：
Fotino, M
中科院分区：
文献类型：
--
作者：
Fu, S M;Kunkel, H G;Brusman, H P;Allen, F H Jr;Fotino, M
对一个C2缺陷家系的HL-A分析表明，C2缺陷与组织相容性HL-A基因座有密切的连锁关系。先证者为C2缺乏和HL-A单倍型10，W18纯合子。在三个双回交后代中，未发现重组子，并讨论了这种连锁的可能意义。
HL-A analysis of a family with C2 deficiency revealed evidence for close linkage between the C2 defect and the histocompatibility HL-A loci. The propositus was homozygous both for C2 deficiency and the HL-A haplotype 10,W18. Among seven children of three double backcross matings, no recombinants were found. The possible significance of such linkage is discussed.