Functionalization of (-)-β-pinene and (-)-limonene via cross metathesis with symmetrical internal olefins
Functionalization of (-)-β-pinene and (-)-limonene via cross metathesis with symmetrical internal olefins
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DOI：
10.1016/j.catcom.2019.105893
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发表时间：
2020-02-01
影响因子：
3.7
通讯作者：
Bruneau, Christian
中科院分区：
文献类型：
--
作者：
Fernandes, Luciana Sarmento;Mandelli, Dalmo;Bruneau, Christian
描述了天然产物β-蒎烯和柠檬烯通过与对称的内烯烃的交叉复分解反应，实现了对空间要求很高的α，α-二取代双键的直接功能化。该反应以Hoveyda-GRubbs型Ru催化剂为催化剂，以碳酸二甲酯为绿色溶剂，使酯基和腈基团的一步干净引入成为可能，不会产生副产物。
The straightforward functionalization of sterically demanding alpha,alpha-disubstituted double bonds of the natural products beta-pinene and limonene via cross metathesis with symmetrical internal olefins is described. The reaction is catalyzed by Hoveyda-Grubbs type ruthenium catalysts in dimethyl carbonate as green solvent and makes possible the clean introduction of ester and nitrile groups in one step without formation of byproducts.