Intravascular large B-cell lymphoma or intravascular lymphomatosis: report of a case diagnosed by testicle biopsy
Intravascular large B-cell lymphoma or intravascular lymphomatosis: report of a case diagnosed by testicle biopsy
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DOI：
10.1007/s002770000268
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发表时间：
2001-05-01
影响因子：
3.5
通讯作者：
Berneman, Z
中科院分区：
文献类型：
--
作者：
Van Droogenbroeck, J;Altintas, S;Berneman, Z
血管内大b细胞淋巴瘤或血管内淋巴瘤病（IVL）是一种极为罕见的非霍奇金淋巴瘤。最常见的临床症状是不明原因发热（FUO）。组织学上，血管腔内可见恶性淋巴样细胞增生。细胞学上，这些细胞具有与经典大细胞淋巴瘤相似的特征。肺动脉血检查显示本例患者存在这种异常人群；据我们所知，在IVL中检测循环肿瘤细胞的其他报告只有四份。结果很糟糕。诊断最常在皮肤或大脑活检后作出，但通常在死后确定。我们提出什么是-据我们所知-第一例IVL诊断后活检睾丸。在FUO和怀疑恶性肿瘤的情况下，IVL -尽管非常罕见-应该作为鉴别诊断之一。
Intravascular large B-cell lymphoma or intravascular lymphomatosis (IVL) is an extremely rare form of non-Hodgkin's lymphoma. The most common clinical sign is fever of unknown origin (FUO). Histologically, there is proliferation of malignant lymphoid cells within vascular lumina. Cytologically, the cells have features similar to those found in classical large cell lymphoma. Examination of pulmonary artery blood showed the presence of this abnormal population in our patient; to the best of our knowledge there are only four other reports of detection of circulating tumor cells in IVL. The outcome is very poor. The diagnosis is most frequently made after biopsy of skin or brain but is often established post mortem. We present what is - to our knowledge - the first reported case of IVL diagnosed after biopsy of a testicle. In the event of FUO and suspicion of a malignancy, IVL - although very rare - should be one of the differential diagnoses.