Optimizing the laser-pulse configuration for coherent Raman spectroscopy
Optimizing the laser-pulse configuration for coherent Raman spectroscopy
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DOI：
10.1126/science.1139055
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发表时间：
2007-04-13
期刊：
影响因子：
56.9
通讯作者：
Scully, Marlan O.
中科院分区：
文献类型：
--
作者：
Pestov, Dmitry;Murawski, Robert K.;Scully, Marlan O.
我们介绍了一种混合技术，结合了频率分辨相干反斯托克斯拉曼散射（汽车）的鲁棒性与时间分辨汽车光谱的优点。几个特征分子振动的瞬时相干宽带激发和随后通过最佳形状的时间延迟的窄带激光脉冲探测这些振动有助于抑制非共振背景和检索物种特异性信号。我们使用这种技术的相干拉曼光谱的吡啶二羧酸钠粉末，这是类似的吡啶二羧酸钙（细菌内生孢子的标记分子，如枯草芽孢杆菌和炭疽芽孢杆菌），我们证明了一个快速和高度特异性的检测方案，即使在存在多重散射。
We introduce a hybrid technique that combines the robustness of frequency-resolved coherent anti-Stokes Raman scattering (CARS) with the advantages of time-resolved CARS spectroscopy. Instantaneous coherent broadband excitation of several characteristic molecular vibrations and the subsequent probing of these vibrations by an optimally shaped time-delayed narrowband laser pulse help to suppress the nonresonant background and to retrieve the species-specific signal. We used this technique for coherent Raman spectroscopy of sodium dipicolinate powder, which is similar to calcium dipicolinate ( a marker molecule for bacterial endospores, such as Bacillus subtilis and Bacillus anthracis), and we demonstrated a rapid and highly specific detection scheme that works even in the presence of multiple scattering.