Antimicrobial activity of essential oils against Helicobacter pylori
Antimicrobial activity of essential oils against Helicobacter pylori
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DOI：
10.1046/j.1523-5378.2003.00146.x
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发表时间：
2003-06-01
期刊：
影响因子：
4.4
通讯作者：
Imanishi, J
中科院分区：
文献类型：
--
作者：
Ohno, T;Kita, M;Imanishi, J
背景幽门螺杆菌是导致人类胃十二指肠疾病的重要病原体。虽然H.幽门螺杆菌使用抗生素往往改善胃十二指肠。疾病，对抗生素的耐药性正在出现。通过体外和体内试验，评价了精油的抗菌作用和对精油的耐药性。本研究中使用的13种精油完全抑制H. pylori在体外以0.1%（v/v）的浓度。香茅和柠檬马鞭草对H. pH4.0和5.0时，pylori浓度为0.01%。耐柠檬草没有发展，即使经过10个连续的通道，而耐克拉霉素在相同的条件下开发。在体内研究中，H.与未处理的小鼠相比，用柠檬草处理的小鼠胃中的幽门螺杆菌显著减少。这些结果表明，精油对H. pylori感染而不产生获得性耐药性，这表明精油可能具有作为新的和安全的抗幽门螺杆菌药物的潜力。幽门螺杆菌治疗方案。
Background. Helicobacter pylori is an important pathogen responsible for gastroduodenal diseases in humans. Although the eradication of H. pylori using antibiotics often improves gastroduodenal. diseases, resistance to the antibiotics is emerging.Materials and Methods. The antimicrobial effect of essential oils and the development of resistance to the essential oils were evaluated in vitro and in vivo.Results. Thirteen essential oils used in this study completely inhibited the growth of H. pylori in vitro at a concentration of 0.1% (v/v). Cymbopogon citratus (lemongrass) and Lippia citriodora (lemon verbena) were bactericidal against H. pylori at 0.01% at pH 4.0 and 5.0. Resistance to lemongrass did not develop even after 10 sequential passages, whereas resistance to clarithromycin developed under the same conditions. In in vivo studies, the density of H. pylori in the stomach of mice treated with lemongrass was significantly reduced compared with untreated mice.Conclusions. These results demonstrate that the essential oils are bactericidal against H. pylori without the development of acquired resistance, suggesting that essential oils may have potential as new and safe agents for inclusion in anti-H. pylori regimens.