Protein kinases and protein phosphatases in prokaryotes: a genomic perspective.
Protein kinases and protein phosphatases in prokaryotes: a genomic perspective.
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DOI：
10.1111/j.1574-6968.2002.tb10978.x
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发表时间：
2002-01
影响因子：
2.1
通讯作者：
P. Kennelly
中科院分区：
文献类型：
--
作者：
P. Kennelly
多年来，通过磷酸化和去磷酸化调节蛋白质结构和功能被认为是相对较新的发明，在每个系统发育域中独立出现。然而，随着时间的推移，涉及“真核”蛋白激酶或蛋白磷酸酶在原核生物中的存在的表观结构域侵入事件的报道越来越频繁。今天，基因组学已经提供了一种全面和系统地研究真核生物蛋白激酶和蛋白磷酸酶系统发育分布的方法。这些基因组搜索的结果挑战了以前关于这种多功能调节机制的起源和进化的概念。
For many years, the regulation of protein structure and function by phosphorylation and dephosphorylation was considered a relatively recent invention that arose independently in each phylogenetic domain. Over time, however, incidents of apparent domain trespass involving the presence of 'eukaryotic' protein kinases or protein phosphatases in prokaryotic organisms were reported with increasing frequency. Today, genomics has provided the means to examine the phylogenetic distribution of 'eukaryotic' protein kinases and protein phosphatases in a comprehensive and systematic manner. The results of these genome searches challenge previous conceptions concerning the origins and evolution of this versatile regulatory mechanism.