Anatomical details affect electric field predictions for non-invasive brain stimulation in non-human primates.
Anatomical details affect electric field predictions for non-invasive brain stimulation in non-human primates.
复制标题
解剖细节影响非人类灵长类动物非侵入性脑刺激的电场预测。
DOI：
10.1016/j.neuroimage.2023.120343
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发表时间：
2023
期刊：
影响因子：
5.7
通讯作者：
Opitz,Alexander
中科院分区：
文献类型：
--
作者：
Mantell,KathleenE;Perera,NipunD;Shirinpour,Sina;Puonti,Oula;Xu,Ting;Zimmermann,Jan;Falchier,Arnaud;Heilbronner,SarahR;Thielscher,Axel;Opitz,Alexander
非人灵长类动物（NHPs）已成为无创脑刺激（NIBS）转化研究的关键。然而，为了为人类创造可比较的刺激条件，研究跨物种当前建模实践的准确性至关重要。模拟电场的数值模型是NHPs实验规划和转化为人类研究的重要工具。因此，在计算NIBS电场时，NHP模型的解剖细节是否以及在多大程度上与当前的建模实践一致是至关重要的。在这里，我们创建了两种非人类灵长类动物（NHP） MR数据的高精度头部模型。我们评估了肌肉组织和头部视野（取决于MRI参数）如何影响经颅电和磁刺激（TES和TMS）的模拟结果。我们的研究结果表明，各向异性肌肉的包含可以影响TES电场强度高达22%，而TMS在很大程度上不受影响。此外，比较完整的头部模型和裁剪的头部模型说明了头部视野对电场的影响，无论是TES还是TMS。我们发现，与完整头部模型相比，剪头模型的TES和TMS之间存在相反的效应，TES增加了24.8%，TMS减少了24.6%。我们的研究结果为NHP头部模型所需的解剖细节水平提供了重要的见解，并可以为NIBS研究的未来转化工作提供信息。
Non-human primates (NHPs) have become key for translational research in noninvasive brain stimulation (NIBS). However, in order to create comparable stimulation conditions for humans it is vital to study the accuracy of current modeling practices across species. Numerical models to simulate electric fields are an important tool for experimental planning in NHPs and translation to human studies. It is thus essential whether and to what extent the anatomical details of NHP models agree with current modeling practices when calculating NIBS electric fields. Here, we create highly accurate head models of two non-human primates (NHP) MR data. We evaluate how muscle tissue and head field of view (depending on MRI parameters) affect simulation results in transcranial electric and magnetic stimulation (TES and TMS). Our findings indicate that the inclusion of anisotropic muscle can affect TES electric field strength up to 22% while TMS is largely unaffected. Additionally, comparing a full head model to a cropped head model illustrates the impact of head field of view on electric fields for both TES and TMS. We find opposing effects between TES and TMS with an increase up to 24.8% for TES and a decrease up to 24.6% for TMS for the cropped head model compared to the full head model. Our results provide important insights into the level of anatomical detail needed for NHP head models and can inform future translational efforts for NIBS studies.