CEREBRAL BLOOD-FLOW, BLOOD-VOLUME AND OXYGEN UTILIZATION - NORMAL VALUES AND EFFECT OF AGE
CEREBRAL BLOOD-FLOW, BLOOD-VOLUME AND OXYGEN UTILIZATION - NORMAL VALUES AND EFFECT OF AGE
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DOI：
10.1093/brain/113.1.27
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发表时间：
1990-02-01
期刊：
影响因子：
14.5
通讯作者：
JONES, T
中科院分区：
文献类型：
--
作者：
LEENDERS, KL;PERANI, D;JONES, T
本文应用~（15）O稳态吸入法和正电子发射断层扫描仪测定了34例健康志愿者（年龄22-82岁）的局部脑血流量（CBF）、氧摄取率（OER）、氧利用率（CMRO_2）和血容量（CBV）。受试者之间的CBF与CMRO 2呈正相关，虽然测量值的个体间变异性很大。OER不依赖于CMRO 2，但与CBF呈高度负相关。CBV与CBF呈正相关。当考虑单个受试者内所有感兴趣区域的值时，发现CMRO 2和CBF之间以及CBF和CBV之间存在严格耦合，而OER是恒定的并且独立于CBF和CMRO 2。在“纯"灰质和白色区，CMRO 2、CBF和CBV随年龄的增长每年下降约0.50%。在其他区域，下降不太明显，很可能是部分数量效应所致。OER没有变化或显示出轻微的增加，随着年龄的增长（最大的灰质区域0.35%年）。结果表明随着年龄的增长，神经元放电减少或树突突触密度降低。
Regional cerebral blood flow (CBF), oxygen extraction ratio (OER), oxygen utilization (CMRO2) and blood volume (CBV) were measured in a group of 34 healthy volunteers (age range 22-82 yrs) using the 15O steady-state inhalation method and positron emission tomography. Between subjects CBF correlated positively with CMRO2, although the interindividual variability of the measured values was large. OER was not dependent on CMRO2, but highly negatively correlated with CBF. CBV correlated positively with CBF. When considering the values of all the regions of interest within a single subject, a strict coupling between CMRO2 and CBF, and between CBF and CBV was found, while OER was constant and independent of CBF and CMRO2. In ''pure'' grey and white matter regions CMRO2, CBF and CBV decreased with age approximately 0.50% per year. In other regions the decline was less evident, most likely due to partial volume effects. OER did not change or showed a slight increase with age (maximum in the grey matter region 0.35% yr). The results suggest diminished neuronal firing or decreased dendritic synaptic density with age.