Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects
Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects
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DOI：
10.1016/s0261-5614(03)00059-1
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发表时间：
2003-12-01
影响因子：
6.3
通讯作者：
Choi, MS
中科院分区：
文献类型：
--
作者：
Jung, UJ;Kim, HJ;Choi, MS
背景和目的：初步研究表明，柚皮苷对高胆固醇饲料喂养的动物具有明显的降脂作用和抗氧化作用。因此，本研究旨在探讨柚皮苷对高胆固醇血症患者的影响。方法：根据受试者的血浆胆固醇水平，建立高胆固醇血症组(n=30)和健康对照组(n=30)，所有受试者均给予常规饮食的柚皮苷(400 mg/粒/粒)，疗程8周。结果：在高胆固醇血症患者中，补充柚皮苷可使血浆总胆固醇和低密度脂蛋白胆固醇浓度分别降低14%和17%，而对血浆甘油三酯和高密度脂蛋白胆固醇浓度无影响。高胆固醇血症患者治疗后载脂蛋白B水平显著降低，而载脂蛋白A-1水平无明显变化。高胆固醇血症组红细胞超氧化物歧化酶和过氧化氢酶活性显著升高，而谷胱甘肽过氧化物酶活性和血浆总胆红素水平与基础值无明显差异。同时，补充柚皮苷对对照组大鼠的血脂、载脂蛋白、总胆红素水平及抗氧化酶活性无影响。结论：因此，这些数据表明，柚皮苷可能在降低高胆固醇血症患者的血浆胆固醇和调节抗氧化能力方面发挥重要作用。(C)2003爱思唯尔科学有限公司。保留所有权利。
Background and aims: Preliminary studies have shown that naringin has a potent lipid-lowering effect and antioxidant capacity in high-cholesterol diet fed animals. Accordingly, the present study was conducted to investigate the effect of naringin on hypercholesterolemic subjects. Methods: A hypercholesterolemic group (n = 30) and healthy control group (n = 30) were established based on the plasma cholesterol levels in the subjects, then all subjects received naringin (400 mg/capsule/clay) with regular meals for a period of 8 weeks. Results: In the hypercholesterolemic subjects, naringin supplementation was found to lower the plasma total cholesterol by 14% and low-density lipoprotein cholesterol concentrations by 17%, while the plasma triglycericle and high-density lipoprotein cholesterol concentrations remained unaffected. The apolipoprotein B levels in the hypercholesterolemic subjects were significantly lowered after naringin treatment, yet no change was observed in the apolipoprotein A-1 levels. The erythrocyte superoxide dismutase and catalase activities in the hypercholesterolemic group were significantly increased, whereas the glutathione peroxidase activity and plasma TBARS levels were not different from the baseline measurements. Meanwhile, naringin supplementation had no affect on plasma lipids, apolipoproteins, and TBARS levels or antioxidant enzyme activities in the control group. Conclusions: Therefore, these data suggest that naringin may play an important role in lowering plasma cholesterol and regulating the antioxidant capacity in hypercholesterolemic subjects. (C) 2003 Elsevier Science Ltd. All rights reserved.