A homolog of Drosophila grainy head is essential for epidermal integrity in mice
A homolog of Drosophila grainy head is essential for epidermal integrity in mice
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DOI：
10.1126/science.1107511
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发表时间：
2005-04-15
期刊：
影响因子：
56.9
通讯作者：
Jane, SM
中科院分区：
文献类型：
--
作者：
Ting, SB;Caddy, J;Jane, SM
果蝇的表皮对于维持果蝇的表面屏障防御是必不可少的。角质层弹性不可或缺的是转录因子颗粒头，它调节角质层结构成分共价交联所需的酶的产生。我们报告说，在小鼠表皮屏障的形成和维持依赖于哺乳动物同源的粒状头，粒状头样3。追踪该因子的小鼠表现出缺陷的皮肤屏障功能和缺陷的伤口修复，伴随着转氨酶1的表达减少，转氨酶1是参与交联浅表表皮结构组分的关键酶。这些发现表明，涉及维持表皮屏障和诱导组织修复的蛋白质交联的功能机制在7亿年的进化中是保守的。
The Drosophila cuticle is essential for maintaining the surface barrier defenses of the fly. Integral to cuticle resilience is the transcription factor grainy head, which regulates production of the enzyme required for covalent cross-linking of the cuticular structural components. We report that formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy head-like 3. Mice tacking this factor display defective skin barrier function and deficient wound repair, accompanied by reduced expression of transglutaminase 1, the key enzyme involved in cross-linking the structural components of the superficial epidermis. These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution.