Effect of risperidone on sleep in schizophrenia: a comparison with haloperidol
Effect of risperidone on sleep in schizophrenia: a comparison with haloperidol
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利培酮对精神分裂症睡眠的影响：与氟哌啶醇的比较
DOI：
10.1016/s0165-1781(02)00009-4
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发表时间：
2002
影响因子：
11.3
通讯作者：
M. Nagao
中科院分区：
文献类型：
--
作者：
H. Yamashita;S. Morinobu;S. Yamawaki;J. Horiguchi;M. Nagao
本研究的目的是通过多导睡眠图确定非典型抗精神病药物利培酮对精神分裂症患者睡眠指标的影响。对5名单独服用利培酮的精神分裂症患者和5名单独服用氟哌啶醇的精神分裂症患者的睡眠指标进行了比较。这两组人在人口统计学特征或抗精神病药物剂量方面没有差异。利培酮组的慢波睡眠时间明显长于氟哌啶醇组。然而，这些组之间在睡眠变量上没有其他显著差异。利培酮和氟哌啶醇对睡眠的影响差异可能是由于它们对5-HT2受体的不同作用所致。利培酮是一种已知的5-羟色胺-多巴胺拮抗剂，具有改善精神分裂症患者睡眠质量的潜力。
The aim of the present study is to determine the effect of the atypical antipsychotic drug, risperidone on sleep measures in patients with schizophrenia by polysomnography. Sleep measures were compared in five schizophrenic patients who were receiving risperidone alone and five schizophrenic patients who were receiving haloperidol alone. There were no differences between these two groups in their demographic characteristics or doses of antipsychotic medication. The slow wave sleep period was significantly longer in the risperidone-treated group than in the haloperidol-treated group. There were, however, no other significant differences in sleep variables between these groups. This difference in the effect on sleep between risperidone and haloperidol may be due to their differential actions on serotonin (5-HT2) receptors. Risperidone, which is known to be a serotonin-dopamine antagonist, has the potential to improve the quality of sleep in schizophrenic patients.
精神分裂症和抑郁症的快速眼动睡眠眼动。
影响因子：
--
作者：
Benson,KL;ZarconeJr,VP
通讯作者：
ZarconeJr,VP