Acute antidepressant effects of intravenous hydrocortisone and CRH in depressed patients: A double-blind, placebo-controlled study
Acute antidepressant effects of intravenous hydrocortisone and CRH in depressed patients: A double-blind, placebo-controlled study
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DOI：
10.1176/appi.ajp.157.8.1334
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发表时间：
2000-08-01
影响因子：
17.7
通讯作者：
Schatzberg, AF
中科院分区：
文献类型：
--
作者：
DeBattista, C;Posener, JA;Schatzberg, AF
目的：本研究的主要目的是检验静脉输注氢化可的松和羊促肾上腺皮质激素释放激素（CRH）对重度抑郁症患者的急性抗抑郁作用。
方法：22名符合《精神障碍诊断与统计手册》第三版修订本（DSM - III - R）中非精神病性重度抑郁症标准的患者，在第1天被随机分配在双盲条件下接受静脉注射1μg/kg的羊CRH、15mg的氢化可的松或生理盐水。在第1天给予研究药物前以及次日（第2天）完成标准的抑郁评定量表。
结果：接受氢化可的松治疗的患者在22项汉密尔顿抑郁评定量表总分上的降低幅度（平均降低8.4分，即37%）显著大于接受羊CRH（平均降低1.2分）或安慰剂（平均降低1.3分）的患者。
结论：急性氢化可的松输注与抑郁症状的快速且显著减轻相关。作者讨论了这些发现的治疗意义。
Objective: The primary objective of this investigation was to examine the acute antidepressant effects of intravenous hydrocortisone and ovine corticotropin releasing hormone (CRH) infusions in patients with major depression.Method: Twenty-two patients who met DSM-III-R criteria for nonpsychotic major depression were randomly assigned to receive intravenously 1 mu g/kg of ovine CRH, 15 mg of hydro-cortisone, or saline under double-blind conditions on day 1. Standard depression rating scales were completed on day 1 before the study medications were administered and again the following day (day 2).Results: Patients treated with hydrocortisone demonstrated a significantly greater reduction in total 22-item Hamilton Depression Rating Scale scores (mean reduction=8.4 points or 37%) than patients given ovine CRH (mean=1.2 points) or pla cebo (mean=1.3 points).Conclusions: Acute hydrocortisone infusion is associated with a rapid and robust reduction in depressive symptoms. The authors discuss the therapeutic implications of these findings.