Nutrition-dependent control of insect development by insulin-like peptides.
Nutrition-dependent control of insect development by insulin-like peptides.
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DOI：
10.1016/j.cois.2015.08.001
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发表时间：
2015-10-01
影响因子：
5.3
通讯作者：
Yamanaka N
中科院分区：
文献类型：
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作者：
Okamoto N;Yamanaka N
在后生动物中，胰岛素样肽(ILP)家族的成员在响应营养状态的多种生理功能中发挥作用。ILP已在多种昆虫中被鉴定和鉴定。昆虫ILPS主要由大脑中的几对内侧神经分泌细胞产生，在血淋巴中循环，并系统地作用于靶组织。鳞翅目的生理生化研究和果蝇的遗传学研究极大地扩展了我们对ILPS生理功能的认识。在这里，我们概述了昆虫ILPS结构分类的最新进展，并概述了昆虫ILPS在发育过程中参与营养依赖性生长的生理功能的最新研究。
In metazoans, members of the insulin-like peptide (ILP) family play a role in multiple physiological functions in response to the nutritional status. ILPs have been identified and characterized in a wide variety of insect species. Insect ILPs that are mainly produced by several pairs of medial neurosecretory cells in the brain circulate in the hemolymph and act systemically on target tissues. Physiological and biochemical studies in Lepidoptera and genetic studies in the fruit fly have greatly expanded our knowledge of the physiological functions of ILPs. Here, we outline the recent progress of the structural classification of insect ILPs and overview recent studies that have elucidated the physiological functions of insect ILPs involved in nutrient-dependent growth during development.