Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
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DOI：
10.1016/s0092-8674(02)00862-0
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发表时间：
2002-08-23
期刊：
影响因子：
64.5
通讯作者：
Nakafuku, M
中科院分区：
文献类型：
--
作者：
Nakatomi, H;Kuriu, T;Nakafuku, M
成年人的大脑是非常脆弱的。各种侮辱。然而，最近在成年哺乳动物中发现的神经祖细胞，提高了通过招募其潜在的再生潜力来修复受损组织的可能性。在这里，我们表明，激活内源性祖细胞导致大量再生海马锥体神经元缺血性脑损伤后。内源性祖细胞对缺血作出反应而增殖，随后迁移到海马中以再生新的神经元。脑室内输注生长因子显著增强这些反应，从而增加新生神经元的数量。我们的研究表明，再生的神经元整合到现有的大脑回路中，有助于改善神经功能缺损。这些结果扩大了中风和其他神经系统疾病的新型神经细胞再生疗法的可能性。
The adult brain is extremely vulnerable to. various insults. The recent discovery of neural progenitors in adult mammals, however, raises the possibility of repairing damaged tissue by recruiting their latent regenerative potential. Here we show that activation of endogenous progenitors leads to massive regeneration of hippocampal pyramidal neurons after ischemic brain injury. Endogenous progenitors proliferate in response to ischemia and subsequently migrate into the hippocampus to regenerate new neurons. Intraventricular infusion of growth factors markedly augments these responses, thereby increasing the number of newborn neurons. Our studies suggest that regenerated neurons are integrated into the existing brain circuitry and contribute to ameliorating neurological deficits. These results expand the possibility of novel neuronal cell regeneration therapies for stroke and other neurological diseases.