A nickel-mediated oxidative α-C(sp3)-H functionalization of amides with allylic alcohols terminated by radical 1,2-aryl migration
A nickel-mediated oxidative α-C(sp3)-H functionalization of amides with allylic alcohols terminated by radical 1,2-aryl migration
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镍介导的氧化 α-C(sp(3))-H 酰胺与烯丙醇的官能化，通过自由基 1,2-芳基迁移终止
DOI：
10.1039/c4cc08797f
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Wang, Shao-Hua
中科院分区：
文献类型：
--
作者：
Song, Ren-Jie;Tu, Yong-Qiang;Wang, Shao-Hua
通过自由基1，2-芳基迁移反应，研究了N，N-取代酰胺与α，α-二芳基烯丙醇的氧化C(sp(3))-H官能化反应。该工艺具有底物范围广、官能团耐受性好的特点。值得注意的是，在这些条件下，以中等到较好的产率合成了含有全碳四元中心的伽马氨基酮。
A Ni-mediated oxidative C(sp(3))-H functionalization of N,N-substituted amides with alpha,alpha-diaryl allylic alcohols through a radical 1,2-aryl migration process has been developed. This process features a broad substrate scope and excellent functional group tolerance. Notably, gamma-amino ketones containing an all-carbon quaternary center were synthesized under these conditions in moderate to good yields.