Awake, Offline Processing during Associative Learning.
Awake, Offline Processing during Associative Learning.
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DOI：
10.1371/journal.pone.0127522
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Creswell JD
中科院分区：
文献类型：
--
作者：
Bursley JK;Nestor A;Tarr MJ;Creswell JD
离线处理已被证明可以加强记忆痕迹，并在缺乏有意识的排练或意识的情况下增强学习。在这里，我们评估是否一个简短的，两分钟的离线处理期间可以促进联想学习和测试这些离线处理效果的记忆激活帐户。在编码成对的同事后，受试者要么完成两分钟的分心任务，要么立即在一项平衡的受试者内功能性磁共振成像研究中测试对配对的记忆。结果表明，短暂的，清醒的，离线处理提高了联想对的记忆。此外，神经影像数据的多体素模式分析表明，在离线处理过程中，背外侧前额叶皮层的编码记忆表征被重新激活。这些结果首次证明了清醒、主动、离线的联想记忆增强，并表明这种增强伴随着编码记忆表征的离线重新激活。
Offline processing has been shown to strengthen memory traces and enhance learning in the absence of conscious rehearsal or awareness. Here we evaluate whether a brief, two-minute offline processing period can boost associative learning and test a memory reactivation account for these offline processing effects. After encoding paired associates, subjects either completed a distractor task for two minutes or were immediately tested for memory of the pairs in a counterbalanced, within-subjects functional magnetic resonance imaging study. Results showed that brief, awake, offline processing improves memory for associate pairs. Moreover, multi-voxel pattern analysis of the neuroimaging data suggested reactivation of encoded memory representations in dorsolateral prefrontal cortex during offline processing. These results signify the first demonstration of awake, active, offline enhancement of associative memory and suggest that such enhancement is accompanied by the offline reactivation of encoded memory representations.