Impact of omega-3 fatty acids and/or plant sterol supplementation on non-HDL cholesterol levels of dyslipidemic Indian adults
Impact of omega-3 fatty acids and/or plant sterol supplementation on non-HDL cholesterol levels of dyslipidemic Indian adults
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DOI：
10.1016/j.jff.2012.08.001
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发表时间：
2013
影响因子：
5.6
通讯作者：
S. Khandelwal;R. Shidhaye;I. Demonty;R. Lakshmy;Ruby Gupta;D. Prabhakaran;S. Reddy
中科院分区：
文献类型：
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作者：
S. Khandelwal;R. Shidhaye;I. Demonty;R. Lakshmy;Ruby Gupta;D. Prabhakaran;S. Reddy
比较了2g/d鱼油(胶囊)中的长链omega-3脂肪酸(omega-3)和2g/d植物甾醇(酸奶饮料)对印度受试者低密度脂蛋白胆固醇和非高密度脂蛋白胆固醇水平的单独和联合影响。经过两周的磨合期，200名35-55岁的轻度高胆固醇血症(总胆固醇5.0-8.0 mmol/L)的成年人被随机分成四组[(1)两组安慰剂(2)活性omega-3(3)活性植物甾醇(4)均有效]，这是一项2×2因素、双盲、安慰剂对照试验。分别于干预前和干预4周后采集血样(n=178)。使用ANCOVA模型分析血脂水平，相关基线测量作为协变量；调整后的平均数在不同组之间进行比较。虽然植物甾醇显著降低低密度脂蛋白胆固醇(−4.5%；P=0.017)和非高密度脂蛋白胆固醇(−7.9%；P=0.0019)水平，但omega-3没有表现出任何这种影响。合并后的降幅分别为4.2%和3.9%(不显著)。因此，除了目前的发现之外，omega-3-PS组合对血脂水平的有益影响(三酰甘油降低了15%，高密度脂蛋白-C增加了5.4%)，可以使这种组合成为降低印度成年人冠心病风险的有用替代方案。
Independent and combined effects of 2g/d long chain omega-3 fatty acids (omega-3) from fish oil (capsules) and 2g/d plant sterol (yogurt drink) on LDL-C and non-HDL-C levels in Indian subjects were compared. Following a 2-week run-in period, 200 mildly hypercholesterolemic (total cholesterol 5.0–8.0mmol/l) adults (35–55years) were randomized into one of four groups [(1) both placebo (2) active omega-3 (3) active plant sterol (4) both active] of a 2×2 factorial, double-blind, placebo-controlled trial. Blood samples were obtained before and after the 4-week intervention (n=178). Lipid levels were analyzed using ANCOVA models with relevant baseline measurements as covariates; adjusted means were compared across groups. While plant sterols significantly lowered LDL-C (−4.5%; P=0.017) and non-HDL-C (−7.9%; P=0.0019) levels, omega-3 did not demonstrate any such impact. The combination resulted in 4.2% and 3.9% reduction (non-significant), respectively. Thus, the beneficial effects of the omega-3-PS combination on lipid levels demonstrated earlier (lowered triacylglycerols by 15%, increased HDL-C by 5.4%) in addition to the present findings could make this combination a useful alternative for lowering coronary heart disease risk in Indian adults.