Molecular cross-regulation between PPAR-γ and other signaling pathways: implications for lung cancer therapy.
Molecular cross-regulation between PPAR-γ and other signaling pathways: implications for lung cancer therapy.
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PPAR-γ 和其他信号通路之间的分子交叉调节：对肺癌治疗的影响。
DOI：
10.1016/j.lungcan.2011.01.019
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发表时间：
2011-05
期刊：
影响因子：
5.3
通讯作者：
Keshamouni, Venkateshwar G.
中科院分区：
文献类型：
--
作者：
Reka, Ajaya Kumar;Goswami, Moloy T.;Krishnapuram, Rashmi;Standiford, Theodore J.;Keshamouni, Venkateshwar G.
过氧化物酶体增殖物激活受体-γ属于核激素受体超家族的配体依赖性转录因子。它是脂肪细胞分化的中介物，调节脂肪代谢和巨噬细胞功能。PPAR-γ的配体长期以来一直在临床上用于治疗II型糖尿病，具有非常低的毒性。PPAR-γ的激活被证明通过其对肿瘤微环境中多种不同类型的细胞的多效性作用来调节癌症的各种特征。大量的临床前研究表明，PPAR-γ配体通过影响细胞增殖、凋亡、血管生成、炎症和转移等多种细胞过程来控制肿瘤进展。多种信号通路被认为是潜在的作用机制。这篇综述将集中在这些机制的分子基础上；主要讨论PPAR-γ与其他信号通路的交叉调节及其与肺癌治疗的相关性。
Peroxisome Proliferator-Activated Receptors (PPAR)-γ belongs to the nuclear hormone receptor superfamily of ligand-dependent transcription factors. It is a mediator of adipocyte differentiation, regulates lipid metabolism and macrophage function. The ligands of PPAR-γ have long been in the clinic for the treatment of type II diabetes and have a very low toxicity profile. Activation of PPAR-γ was shown to modulate various hallmarks of cancer through its pleiotropic affects on multiple different cell types in the tumor microenvironment. An overwhelming number of preclinical-studies demonstrate the efficacy of PPAR-γ ligands in the control of tumor progression through their affects on various cellular processes, including cell proliferation, apoptosis, angiogenesis, inflammation and metastasis. A variety of signaling pathways have been implicated as potential mechanisms of action. This review will focus on the molecular basis of these mechanisms; primarily PPAR-γ cross-regulation with other signaling pathways and its relevance to lung cancer therapy will be discussed.
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