Acute and specific collagen type I degradation increases diastolic and developed tension in perfused rat papillary muscle
Acute and specific collagen type I degradation increases diastolic and developed tension in perfused rat papillary muscle
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DOI：
10.1152/ajpheart.00967.2001
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发表时间：
2004-03-01
影响因子：
4.8
通讯作者：
Westerhof, N
中科院分区：
文献类型：
--
作者：
Lamberts, RR;Willemsen, MJJMF;Westerhof, N
胶原降解被认为是不同心肌病长期收缩功能障碍的原因，但急性和特定的I型胶原去除(心肌中的主要类型)对张力的影响尚未被研究。用纯化的I型胶原酶，测定大鼠乳头肌等长收缩(灌流压力60cmH(2)O)急性和特异性去除细小胶原柱前后的舒张期和张力期长度关系。在最大长度的95%(95%L最大值)时，舒张期张力增加20.4+/-8.1%(P
Collagen degradation is suggested to be responsible for long-term contractile dysfunction in different cardiomyopathies, but the effects of acute and specific collagen type I removal (main type in the heart muscle) on tension have not been studied. We determined the diastolic and developed tension length relations in isometric contracting perfused rat papillary muscles (perfusion pressure 60 cmH(2)O) before and after acute and specific removal of small collagen struts with the use of purified collagenase type I. At 95% of the maximal length (95% L-max), diastolic tension increased 20.4+/-8.1% (P