Maternal macho-1 is an intrinsic factor that makes cell response to the same FGF signal differ between mesenchyme and notochord induction in ascidian embryos
Maternal macho-1 is an intrinsic factor that makes cell response to the same FGF signal differ between mesenchyme and notochord induction in ascidian embryos
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DOI：
10.1242/dev.00732
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发表时间：
2003-11-01
期刊：
影响因子：
4.6
通讯作者：
Nishida, H
中科院分区：
文献类型：
--
作者：
Kobayashi, K;Sawada, K;Nishida, H
细胞外信号分子作用于几种类型的细胞，根据信号接收细胞中的内在因素引起特征性和不同的反应。在海鞘胚胎中，脊索和间充质分别由内胚层前体发出的相同FGF信号在植物半球的前缘和后缘诱导。反应性的差异取决于后植物卵细胞质的遗传。我们发现，马赫-1，首先确定为一个本地化的肌肉决定因素，也需要间充质诱导，它发挥了作用，使脊索和间充质诱导之间的细胞反应不同。一个合子事件涉及蜗牛表达下游的母亲的马赫-1介导的抑制脊索诱导间充质前体。
An extracellular signaling molecule acts on several types of cells, evoking characteristic and different responses depending on intrinsic factors in the signal-receiving cells. In ascidian embryos, notochord and mesenchyme are induced in the anterior and posterior margins, respectively, of the vegetal hemisphere by the same FGF signal emanating from endoderm precursors. The difference in the responsiveness depends on the inheritance of the posterior-vegetal egg cytoplasm. We show that macho-1, first identified as a localized muscle determinant, is also required for mesenchyme induction, and that it plays a role in making the cell response differ between notochord and mesenchyme induction. A zygotic event involving snail expression downstream of maternal macho-1 mediates the suppression of notochord induction in mesenchyme precursors.