Fluid administration, brain edema, and cerebrospinal fluid lactate and glucose concentrations in experimental Escherichia coli meningitis.
Fluid administration, brain edema, and cerebrospinal fluid lactate and glucose concentrations in experimental Escherichia coli meningitis.
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实验性大肠杆菌脑膜炎中的液体给药、脑水肿以及脑脊液乳酸和葡萄糖浓度。
DOI：
10.1093/infdis/168.2.473
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Sande,MA
中科院分区：
文献类型：
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作者：
Täuber,MG;Sande,E;Fournier,MA;Tureen,JH;Sande,MA
在实验性大肠杆菌性脑膜炎家兔中，比较了无液体与大量补充液体对脑水肿和脑脊液（CSF）乳酸和葡萄糖浓度的影响。实验期间（19 h）的液体限制导致体重下降0.5%，而高液体方案使体重增加0.5%。与对照组相比，感染动物出现脑水肿，但液体方案对水肿程度没有可测量的影响。相比之下，液体限制动物的CSF乳酸盐浓度显著高于液体补充动物，而CSF葡萄糖浓度显著低于液体补充动物（乳酸盐，13.5 ± 3.5 vs. 10.1 ± 3.3 mmol/L;葡萄糖，1.89 ± 1.39 vs. 4.11 ± 1.39 mmol/L）。这些结果不能支持在该革兰氏阴性细菌性脑膜炎模型中给予大量液体会加重脑水肿的假设。
The effect of no fluids versus liberal fluid supplementation on brain edema and cerebrospinal fluid (CSF) lactate and glucose concentrations was compared in rabbits with experimental Escherichia coli meningitis. Fluid restriction for the duration of the experiment (19 h) led to a decrease in body weight by ∼5%, while the high fluid regimen increased body weight by ∼5%. Infected animals developed brain edema compared with controls, but the fluid regimen had no measurable effect on the degree of edema. In contrast, fluid-restricted animals had significantly higher CSF lactate and lower CSF glucose concentrations than fluid-supplemented animals (lactate, 13.5 ± 3.5 vs. 10.1 ± 3.3 mmol/L; glucose, 1.89 ± 1.39 vs. 4.11 ± 1.39 mmol/L). These results fail to support the hypothesis that administration of large amounts of fluid in this model of gram-negative bacterial meningitis aggravates brain edema.