Translating intermediate phenotypes to psychopathology: The NIMH Research Domain Criteria
Translating intermediate phenotypes to psychopathology: The NIMH Research Domain Criteria
复制标题
DOI：
10.1111/psyp.12342
复制
发表时间：
2014-12-01
期刊：
影响因子：
3.7
通讯作者：
Cuthbert, Bruce N.
中科院分区：
文献类型：
--
作者：
Cuthbert, Bruce N.
研究领域标准项目(RDoC)由国家精神卫生研究所于2009年初发起，旨在开发基于可观察行为和神经生物学测量的维度对精神障碍进行分类的新方法，用于研究目的。RDoC为精神病理学研究提供了一个框架，旨在通过研究相关的大脑-行为关系来阐明功能损害的具体方面，而不是目前由各种症状分组定义的不同类别的精神障碍。内表型自然符合RDoC的背景，因为它们通常被认为比更抽象的障碍类别更接近基本的神经和心理机制。因此，内表型的基因组方面对于在这样一种精神病理学方法中理解遗传风险架构具有特别重要的意义。
The Research Domain Criteria project (RDoC) was initiated by the National Institute of Mental Health in early 2009 to develop, for research purposes, new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures. RDoC provides a framework for psychopathology research intended to explicate specific aspects of functional impairment by studying relevant brain-behavior relationships, in contrast to the current heterogeneous categories of mental disorders defined by various groupings of symptoms. Endophenotypes fit naturally into the RDoC context since they are typically conceived to be closer to fundamental neural and psychological mechanisms than more abstracted disorder categories. Consequently, the genomic aspects of endophenotypes take on particular significance for understanding genetic risk architectures in such an approach to psychopathology.